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& Mochizuki, H

In another pilot-scale phase I clinical trial using ADI-PEG20 with docetaxel on different solid tumors like non-small cell lung cancer, castrate resistant prostate cancer and head and neck squamous cell carcinoma [142]

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In addition to the direct suppression of TYR catalytic activity, other methods for the disruption of melanogenesis include the post-transcriptional control of TYR, regulation of melanosome transfer and the suppression TYR transcription by suppressing upstream signaling pathways