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Previously, we reported that ( R )-2-hydroxyglutarate (( R )-2HG), the product of mutant isocitrate dehydrogenase (IDH) oncoproteins, competitively inhibits branched-chain amino acid transaminase (BCAT)-dependent glutamate synthesis 14 (Fig

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Once tumours had been reduced to their minimal volume, ferrostatin-1 was withdrawn, unmasking the GPX4 KO effect in these residual tumours

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Caution is also advised in patients with conditions such as asthma, cardiac disease, renal impairment, migraine, or epilepsy, as HCG can lead to fluid retention that may worsen these conditions