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Specifically, fructose increased the activity of LAMP2A and TFEB, changes that are associated with altered expression of genes involved in the ferroptosis pathway, potentially enhancing the malignant characteristics of ovarian cancer stem cells (22)

This oxidative stress resulted in mitochondrial dysfunction, which was depicted by a loss of viability, or mitochondrial membrane potential (m), and loss of mitochondrial health, or mitochondrial mass

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doi: 10.1016/j.tplants.2006.07.002 66 LvY.ZhaoY.HeY.WangJ.ZhengY.ChenX.et al