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However, in agreement with a causal role of moderately elevated circulating homocysteine levels in cardiovascular disease, some putative mechanisms have been identified that may explain the atherothrombogenicity of hyperhomo- cysteinemia

A multi-year open-label observational study in elderly patients reported improvements in self-reported sleep quality and physical performance scores, although study designs lacked blinding and modern placebo control

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L-carnitine also supported joint comfort and functionality in human clinical studies [23,2830].* L-carnitine may do so partially by helping to maintain a healthy weight, resulting in less burden on joints

In cases where inflammation is prominent, immunosuppressive therapies may be warranted to prevent further nerve damage and improve patient outcomes