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Miranda M, Morici JF, Zanoni MB, Bekinschtein P (2019) Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain

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FIGURE 4 To overcome this limitation, numerous high-throughput screening efforts to identify CBS inhibitors have been conducted, but a truly CBS-selective compound has yet to be discovered ( 50 value of 1 M for CBS and shows approximately 30-fold higher inhibitory activity toward CBS than toward CSE (Figure 4B) ( K d ) to be 0.6 M