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Iron can also collaborate with ROS-producing enzymes, such as NADPH oxidases (NOXs), xanthine oxidases, lipoxygenases (LOXs), and cytochrome P450 enzymes to promote the production of intracellular ROS [61]

However, evidence for a consistent association between BCAA levels and lung function parameters such as FEV 1 and FEV 1 /FVC remains insufficient, requiring validation in larger-scale and longitudinal cohort studies (106)

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Therefore, targeting the restoration of pericyte function and promoting microvascular patency are promising for future neuroprotective strategies [23]

A randomized clinical trial involving 141 individuals with autism showed significant metabolic improvements and reductions in core symptoms like hyperactivity and tantrums after supplementation