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Transient and mild stress (such as transient ischemic preconditioning) can induce moderate mitophagy to exert a protective effect, while sustained and high-intensity stress (such as long-term severe ischemia and severe oxidative stress) is prone to trigger excessive mitophagy, shifting the regulatory effect toward damage

The rate of congenital malformations among babies born to mothers using valproate is about four times higher than the rate among babies born to epileptic mothers using other anti-seizure monotherapies

Butt HZ, Atturu G, London NJ, Sayers RD, Bown MJ

The 3-phosphoglycerate produced can then re-enter the glycolytic pathway at the reaction catalyzed by phosphoglycerate mutase, i.e., the eighth step of the pathway