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Clinical trials have shown a 24% increase in skin hydration and a 62% reduction in skin roughness within 12 weeks of consistent supplementation (NIH)

found that after myocardial infarction, IGF-1R expression was upregulated in the ischemic and paraischemic regions of the heart

Oxidative stress occurs when you have too many free radicals molecules with an odd number of electrons floating around in your body and not enough antioxidants to neutralize them

Sun P, Lu X, Xu C, Sun W, Pan B

Also, spermidine ameliorated obesity-associated NAFLD in mice by increasing the phosphorylation of hepatic AMP-activated protein kinase (AMPK), which in turn inhibited the expression of the lipogenic genes Srebf1c and Fas (239)