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Important limitations include: limited human clinical research

Reduces neuropathic symptoms such as tingling and numbness

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Rat S9 fractions, which are commonly utilised in the Ames test to assess mutagenicity, may be limited in the detection of genotoxic metabolites from aromatic amides due to their poor concordance with human in vivo amide hydrolysis

[14] No published human study administered DSIP to healthy adults for sleep, which is precisely the population buying it