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There are many topoisomerases, and James Wang, one of the discoverers of these enzymes, has described them further

doi: 10.1007/s00438-016-1250-8 80 KangJSongYZhangZWangSLuYLiuX

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Proc Natl Acad Sci USA 116(7):26722680 Zhang H, Wang Z, Liu Z, Du K, Lu X (2021) Protective effects of dexazoxane on rat ferroptosis in doxorubicin-induced cardiomyopathy through regulating HMGB1