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Lancet 1984;2:493495

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"Immune checkpoint inhibitors have revolutionized our approach to the treatment of cancer

The most common symptoms include [14]: Weight loss despite a higher appetite Heart palpitations Nervousness Tremors Difficulty breathing Fatigue Diarrhea or frequent bowel movements Muscle weakness Heat intolerance Sweating more than usual Irregular menstrual cycles Additional possible symptoms include [21]: Anxiety Irritability Difficulty sleeping Irregular heartbeat Goiter Erectile dysfunction or loss of libido Thyroid eye disease (eye bulging, tearing, dryness, irritation, puffy eyelids, inflammation, light sensitivity, blurred vision, pain) [14] Thick, red skin on the shins or tops of the feet How Common Is Hyperthyroidism