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Xing Y, Chen WH, Jia W, Zhang J

rhGH triggered changes in kisspeptin, GnRH, and LH in immature male rats During the prepubertal period, kisspeptin activates the HPG axis and increases sex steroids [36, 37]

Such interventions function as hormetic stimuli that potentiate endogenous cytoprotective systems by inducing the activation and upregulation of Nrf2-dependent transcriptional programs