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As treatments impose selective pressures, sensitive clones are eliminated, while resistant clones survive and proliferate

Smoking history could be evidence of oxidative stress and an impaired oxidant defense system

Drach D, Estrov Z, Zhao S, Drach J, Cork A, Collins D, Kantarjian H, Andreeff M

Free radicals are unstable molecules that can damage cells and may play a role in many health conditions

3.1 Reactive Oxygen Species and Ferroptosis In the electron transport chain, mitochondria produce a large amount of Reactive Oxygen Species (ROS) during normal energy metabolism