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This structural deterioration increases the mechanical stress on the annulus fibrosus, eventually causing the nucleus pulposus to herniate through annular fissures, thereby initiating LDH (110)

1197 While the primary effects of rapamycin are attributed to alterations in T cells, it also inhibits BAFF-mediated mTORC1 signaling in B cells, thereby limiting their proliferation and survival

Hormonal monitoring and interventions, such as scheduling high-risk training activities during phases of lower estrogen levels, could be considered to mitigate this risk

Source: Food and Drug Administration, Esai, Biogen

South M, Costa AP, McMorris C