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A recent study demonstrated that the ability of a p53 variant, a nonsynonymous single-nucleotide polymorphism referred to as P47S found in people of African descent, to transactivate GLS2 was impaired [120, 126]

Architecture of the linker-scaffold in the nuclear pore

These modifications collectively elevate bioavailability to therapeutically relevant levelsachieving up to a 178-fold increase in plasma AUC in humans with specific co-grinding formulations compared to unformulated curcuminwhile facilitating passive tumor accumulation via the EPR effect