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Evening before bed is the dominant protocol because it amplifies the natural nocturnal GH surge (which peaks ~90 minutes into deep sleep)

Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes

doi: 10.1210/en.2015-1546

Cmax and AUC of ipamorelin increased with dose, ranging from 30809 nmol/l and 681823 nmol*h/l, respectively

They are pretty much a free lunch in terms of giving you something extra without any major drawbacks