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There is no downtime you can return to normal activities immediately, though your muscles may feel fatigued or slightly sore for a day or two afterward, similar to post workout muscle soreness

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When B12 levels are chronically low due to poor absorption, the effects can extend beyond fatigue and cognitive symptoms

doi: 10.1186/1471-2172-12-66

Within 48 to 72 hours, your body will begin to make new red blood cells