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Description

Our results demonstrated that these adaptations render cancer cells that survive CDK4/6 inhibition highly sensitive to MYC, glutaminase (GLS1), or mTOR inhibitors and hypoxic conditions

Octreotide (Sandostatin) may be used in persistent cases

Immunoprecipitation was performed with Flag agarose M2 affinity beads (Sigma-Aldrich, A2220, 15 l per sample) or with BUD13 antibody (A303-321A) prebound to protein G Dynabeads beads (20 l per sample)