The World Anti-Doping Agency (WADA) prohibits AOD-9604 as a non-approved substance and potential performance-enhancing agent in athletics, citing concerns about unfair advantage through lean body mass gains (if efficacious, which remains unproven)
However, clinical evidence tells a more nuanced story
References Nature Medicine (2014) Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity PMC (2024) Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions Frontiers in Pharmacology (2024) NNMT: a novel therapeutic target for metabolic syndrome PubMed (2021) LC-MS/MS assay for 5-amino-1-methylquinolinium: pharmacokinetic and oral bioavailability study ResearchGate (2021) Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice PMC (2022) Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice NMN.com / Scientific Reports Role of NNMT inhibition in muscle strength: enhanced grip strength with exercise Swolverine 5-Amino-1MQ mechanism, benefits, stacking and cycling guide PMC Subcutaneous drug injection review: pharmacologic considerations CDC Vaccine administration: subcutaneous route (angle/site
More comfortable shots are easier to stick with, especially if you follow our daily injection routine
If fatigue continues, a clinician may evaluate anemia, thyroid disease, sleep problems, medication effects, mood concerns, or other causes
