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A reappraisal of macrophage polarization in glioblastoma: histopathological and immunohistochemical findings and review of the literature

For decades, methotrexate has been used as a standard of care treatment for cancer patients (Newman and Maddocks, More recently, it has been established that the repression of tumor suppressor genes by methylation, which is dependent on SAM levels, is a key-initiating event for many cancers (Kulis and Esteller, De novo serine synthesis has also been identified as a metabolic vulnerability of many cancers, including non-small cell lung cancer (NSCLC), breast cancer, and melanoma (Locasale et al., Glycine metabolism has also been shown to be important in cancer development and growth

Similarly, the knockout of Gpx1 , facilitated memory impairment induced by -Amyloid in mice (Joo et al., 2020)