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Evidence and regulatory status vary by compound, from FDA-approved indications to research-use-only reproductive signaling peptides

This novel mechanism highlights GADD45 as a stabilizer of SIRT1, extending its role beyond transcriptional and metabolic regulation

Even more intriguing is the fact that none of the inclusion criteria for the above-mentioned studies encompassed tumour markers to potentially discard any ongoing or potential tumour process that, obviously, IGF-1 could accelerate