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Morroniside, a novel GATA3 binding molecule, inhibits hepatic stellate cells activation by enhancing lysosomal acid lipase expression

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This provides direct cellular and molecular evidence for understanding the mechanisms of ferroptosis imbalance in AKD and CKD pathogenesis while offering crucial theoretical and data support for subsequent intervention strategies targeting ferroptosis-promoting pathways in kidney diseases (e.g., cell type-specific iron metabolism modulation and lipid peroxidation inhibition)