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M1 macrophages primarily secrete pro-inflammatory cytokines, such as IL-12 and TNF-, promoting Th1-type immune responses

This is a historical term, which refers to the presence of hereditary CRC and brain tumours, particularly medulloblastomas and gliomas

Similarly, pharmacological NOX inhibition with GKT137831 at 60 mg/kg daily for 10 weeks from DM onset significantly reduced atherosclerotic plaque formation and progression in diabetic mice