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In the cell culture model of Wilsons disease, excessive copper accumulation unleashed a cascade of cellular stress responses, including autophagy, oxidative stress, and inflammation driven in part by the dysregulation of key signalling hubs such as NFKB and AP1

To further examine metabolic responses, plasma glycerol concentrations were measured as a marker of lipolysis

PMID: 176 GavinPGMullaneyJALooDCaoK-AGottliebPAHillMMet al

Clinical trials evaluated AOD-9604 for durations ranging from single doses to 24 weeks of continuous daily administration