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TLR4 triggering by rNAPRT activates an inflammatory signature in human macrophages differentiated from PBMC of healthy donors, as observed also using rNAMPT, promoting robust activation of NF-B signaling, transcription and secretion of pro-inflammatory cytokines, including IL-1, IL-8, TNF-, CCL3, and inflammatory mediators such as caspase-1 (CASP1) and P2X purinoreceptor (124) (Figure 3)