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ROS can trigger and maintain the autoimmune cascade by enhancing cell apoptosis and reducing the efficiency of its clearance, and the resulting accumulation of apoptotic residues promotes the formation of auto-antibodies (33)

The authors speculate that this is due to mitochondrial fission occurring close to sites of non-selective autophagosome formation 71

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Ongoing clinical trials and research are warranted to fully elucidate the optimal dosing, formulation, and integration strategies for silymarin in the therapeutic landscape of liver diseases [180,181,182,183,184,185,186,187,188,189,190,191]