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Epitalons circadian-regulatory action and NAD+s mitochondrial bioenergetic support are considered complementary mechanisms rather than overlapping ones, but combination should follow a clinical review of current medications and hepatic/renal clearance considerations

doi: 10.1016/0047-6374(86)90080-1 327 HuangLEstradaRYappertMCBorchmanD

Since the formation of stable metal-thiolate complexes precludes the direct thiol-disulfide redox potential measurements by usual electrochemical techniques, an indirect method had to be elaborated

PLoS ONE 6:e26915

Ovothiols as free-radical scavengers and the mechanism of ovothiol-promoted NAD (P) H-O2 oxidoreductase activity