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** For larger dogs, feed an additional 3/4 cup per day for each 20 lbs of additional body weight over 80 lbs

doi: 10.3390/ani11010136 13 MeyerJDanielsSUGrindlerSTrscher-MuotterJAlaedinMFrahmJet al

FBS, DMEM, and tissue culture reagents were obtained from Invitrogen (Carlsbad, CA, USA)

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Mutations in AR receptor, AR overexpression, intracrine production, contorted expression of enzymes and cofactors of AR, autonomous activation of AR signaling by cytokines in the absence of androgen ligands, and the presence of multiple splice variants of AR are the main causative agents responsible for the therapeutic failure [12, 13]