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While human clinical trials have not yet been completed, the existing data provides valuable insight into how the compound works and what effects it produces

Results Body weight, fat mass, and cecal mass As expected, obese mice (maintained on an HFD followed by WD) had significantly higher body weights than mice continuously maintained on LD

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Galarraga M, Campion J, Munoz-Barrutia A, Boque N, Moreno H, Martinez JA, Milagro F, Ortiz-de-Solorzano C

2.8.3, COMT activity assay A radiometric assay was performed by RBC using 1 M 50 pM tolcapone as an inhibitor positive control

NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability