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141 Similarly, Li et al designed a nanoparticle system modified with pardaxin peptides that induces ER stress via photodynamic/photothermal therapy, triggering immunogenic cell death and demonstrating enhanced antitumor efficacy

Mechanisms involve Nrf2-dependent upregulation of glutamate cysteine ligase in astrocytes, thereby balancing redox status and oxidative stress (Sharon et al., 2016)

A significant number of studies included individual case reports and case series, underscoring the importance of the Roussel Uclaf Causality Assessment Method (RUCAM) as our primary tool for identifying DILI attributed to specific agents

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