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USA: National Center for Biotechnology Information

In certain pathological conditions, such as atherosclerosis, there is a close interplay between autophagy inhibition and ferroptosis activation, where autophagy suppression alleviates ferroptosis-related cellular damage (101)

The role of the UPR is to restore ER function during stress, suggesting that suppressing -oxidation in the mitochondria is functionally beneficial to achieving ER homeostasis

On these grounds, Zhang and colleagues hypothesized that H 2 S induced VAMP3 degradation through Hrd1 S-sulfhydration and prevented CD36 translocation, thereby alleviating lipid toxicity in the heart tissues of db/db diabetic mice (Yu et al., 2020)