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However, non-genetic mechanisms of resistance to cetuximab were also found, via TAF-mediated stromal remodeling and secretion of various growth factors, including FGF1, FGF2, HGF, TGF-1 and TGF-2 (80)

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Nrf2 then accumulates in the cytoplasm and translocates to the nucleus [25], where the Nrf2-dependent self Neh1 attaches to sMAF transcription factors

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