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In the absence of adequate GPX4, the radical intermediates, readily produced from hydroperoxy-phospholipids, directly oxidize GSH in a 1-electron reaction to generate a strongly pro-oxidant radical, GSH

Neuropharmacology 54(6):901911 Pulikkan J, Maji A, Dhakan DB, Saxena R, Mohan B, Anto MM et al (2018) Gut microbial dysbiosis in Indian children with autism spectrum disorders

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Genome-wide knockout, knockdown, and activation screens are now systematically revealing both canonical and unexpected regulators of autophagy, mitophagy, UPS function, and ER stress adaptation