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These molecules regulate immune-cell functions by activating G protein-coupled receptors and inhibiting HDAC, thereby preserving systemic homeostasis ( 3 Mechanisms of the gut-lung axis in severe pneumonia-related lung injury 3.1 Pathogenic effects of gut microbiota dysbiosis Respiratory viral infections provoke exaggerated immune responses that release pro-inflammatory mediators, recruit immune cells, and ultimately disrupt gut-microbiota homeostasis, thereby inducing intestinal inflammation ( 3.2 The gut-derived second hit hypothesis In severe pneumonia, primary invasion of lung tissue constitutes the initial insult, whereas the intestine may provide a secondary source of injury

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Weve sent them to space and found them among hydrothermal vents on the ocean floor