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After stopping supraphysiologic dosing (1100 g 6.0 mg), 7-10 days is usually enough time to return to baseline

Caloric restriction may regulate the energy sensors in cells, such as the AMPK signaling pathway, affecting the metabolism of astrocytes and enabling them to produce more substances beneficial to neurons, such as neurotrophic factors, thereby protecting neurons from degeneration

The above-mentioned findings point to silibinin as a clinically promising substance that can be further developed as a therapeutic candidate for the prevention and treatment of chronic diseases in humans

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Jin P, Niu X, Zhang F, et al