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Takahashi et al., 1999)

Inspired by intracellular multi-enzyme cascade reactions, researchers initially attempted to construct artificial cascade systems by encapsulating natural enzymes within porous synthetic materials, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs) ( 3 O 4 or Au nanoparticles), effectively resolving stability issues ( Figure 3 )

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PLOS ONE 8 , e77023 (2013)