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This effect is not guaranteed and may be due to placebo effect

Summary: Vitamin B12 supplements can be taken at any time of day, as absorption mechanisms function consistently throughout the 24-hour cycle, with consistency being more important than specific timing

Other B Complex Side Effects and When to See a Doctor Outside of stool changes, you may experience other side effects when taking B complex supplements, including: Diarrhea Facial redness Extreme tiredness Headache Nausea Upset stomach Bright yellow pee However, unless these are persistent or interfere with daily life, you may not need to see a healthcare professional if you experience these effects

Early attempts to treat beta-thalassemia patients by inserting the -globin gene into bone marrow cells, in 1980, were completely unsuccessful and received an avalanche of criticism [115], [116]

Hum Mol Genet 29(7):10831095