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Thus, TfR2 would provide an entry point to the liver for the rapid and specific clearance of toxic heme through the endocytosis of heme-HPX under hemolytic conditions

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The COX and LOX pathways are the primary routes for metabolizing AA into inflammatory mediators and breaking it down into leukotrienes, prostaglandins, and some peroxides [58]

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When GH levels remain artificially elevated without the natural pulsatile pattern, somatostatin (the hormone that inhibits GH release) upregulates to restore homeostasis