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In addition, this structure was solved apo or in complex with glutathion allowing a verification of the residues of human MRP1 liganding the substrate

For example, the inhibition of mTOR enabled TFEB dephosphorylation and translocation the later increased the expression of genes encoding lysosomal proteins, such as V-ATPases, lysosomal transmembrane proteins, and hydrolases 93

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10.3389/fmed.2020.629413 Front Med

While current strategies focus on metabolic support and damage mitigation, the horizon includes transformative technologies capable of directly editing the mitochondrial genome