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In the 5xFAD transgenic mouse model of AD, treatment with slow-release niacin (niaspan R ) increases microglia engagement with plaques, reduces plaque number and area, and promotes expression of microglial genes related to phagocytosis [10]

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the structural heterogeneity of the polysaccharides, the lack of clinical trials evaluating the safety and efficacy of the polysaccharides as a treatment for ulcerative colitis, and the large variation in how individuals respond to changes in the composition of the gastrointestinal tract microbiota

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