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The effect of hypoxia-induced exosomes on anti-tumor immunity and its implication for immunotherapy

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In acute gout, MSU crystals, liberated from tissue deposits by remodeling effects or microtrauma, stimulate inflammatory cascades that involve complement activation and assembly of the C5b-9 membrane attack complex, and release of multiple inflammatory cytokines, including IL-1 and the chemokines IL-8 (CXCL8) and GRO- (CXCL1)

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[DOI] [PubMed] Utzschneider KM, Kahn SE

From non-malignant cells to cancer cells Among the various directions of mitochondrial exchange, the transfer from non-malignant to cancer cells has been most extensively reported in tumor-related studies