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Therefore, in line with the current definition of TDP-43 pathology, this mouse model has been considered one of the most reliable models for TDP-43 pathology, especially in the cortex 16,19,39,40,41,42,43

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S7D-F, S8-10).Of note: TDP-43 K408R/+ mice are generally omitted from figures for clarity to avoid confounding variables that may arise due to asymmetric regulation of wild type and K408R alleles due to the autoregulatory nature of TDP-43 (i.e