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Dec 2009;22(4):262-265

Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects

By modulating many pathways (such as p53, FOXO, Nrf2, NF-B), among other things, it can participate in the control of oxidative stress, inflammatory reactions, apoptosis, and the breakdown of energy

Overall, although these strategies highlight the impressive preclinical potential of NM-based macrophage immunotherapy, very few have directly entered the clinical arena