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Inter-compound interactions were evaluated using the Bliss model of independence (Bliss, 1939

Dox@pssp-hh NPS is also a novel nano-delivery system that, in addition to promoting drug diffusion by reducing tumor stromal pressure, the highly expressed Glutathione within tumors can disrupt disulfide bonds in nanoparticles, thereby increasing drug delivery and drug resistance, promote structural changes in nanoparticles to release Dox, which is also associated with the production of reactive oxygen species, further inducing oxidative stress in tumor cells [287]