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DJ-1 acts as a redox-sensitive chaperone

Temporary S-glutathionylation of enzymes in the TCA cycle, ETC, or -oxidation pathway protects them from irreversible oxidation when ROS is high but may also hypothetically serve as a mechanism to diminish mitochondrial ROS production by reducing their activity [51]

Liposomal Glutathione supplement is an antioxidant that promotes the integrity of glutathione during digestion

Unfortunately, no concrete evidence of their efficacy exists to support their beneficial use in addressing the symptoms of mitochondrial diseases [9, 10]

Surprisingly, we also identified an essential, non-canonical function of the glutathione synthesis enzyme GCLC under cystine starvation conditions