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Senescent Leydig Cell Elimination & Testosterone Restoration in Aged Mice (Aging / PMC, 2020) FOXO4-DRI Disrupts FOXO4-p53 in Senescent Leydig Cells and Improves Testicular Microenvironment A study published in Aging (and indexed on PMC) demonstrated that FOXO4 is specifically expressed in human Leydig cells, with nuclear translocation of FOXO4 in elderly men correlating with decreased testosterone synthesis

Good candidates for this treatment include any adult who would like to increase their metabolism and burn fat more quickly

Expect visible results by 8-12 weeks, with continued improvement through 6-12 months

During this proliferative phase, the body is actively building new granulation tissue and initiating neovascularization

However it does not reduce mortality and is often associated with acute kidney injury [44]