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Materials and methods Animals and experimental design Nine-week-old male Fischer 344 rats (Charles River Laboratory, Japan), weighing from 180-200 g, were maintained at 23C, given standard laboratory chow and water ad libitum, and kept under a 12 h light (7:00-19:00)/12 h dark schedule

Of these 23 articles, 7 were systematic reviews and/or meta-analyses, 15 were randomized clinical trials, non-controlled clinical trials, or observational studies, and 1 article related to practice guidelines