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A research guide to the component mechanisms and the co-administration rationale

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Because correction of the underlying metabolic disorder generally results in correction of acid-base abnormalities and because of the potential risks of sodium bicarbonate therapy in the treatment of this disorder, administration of sodium bicarbonate is generally reserved for the treatment of severe acidosis (e.g., arterial pH less than 7-7.15 or serum bicarbonate concentration of 8 mEq/L or less)

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Based on the speech therapists evaluation, BTX-A injections are administered into the mimic muscles indicated, with the objective of reducing hypertonus, synkinesis and improving symmetry