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Yet, much of the mechanistic findings rely on supraphysiological Mn doses in vitro and need confirmation at physiologically relevant Mn concentrations in vivo

Notably, imipramine, by activating the FAM3A-ATP-P2 receptor-CaM-FOXA2-CPT2 pathway, decreases lipid accumulation in hepatocytes, suggesting its potential as a beneficial antidepressant for individuals with concurrent metabolic disorders (290)

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Downregulating factors NF-B (Nuclear Factor kappa-light-chain-enhancer of activated B cells) represses eNOS expression, particularly in inflammation