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And previous studies in our laboratory have shown that conversion of Cys residues into Sec residues in GPx1 and GPx4 could result in dramatic loss of the catalytic activity 15,16

However, these diets often require strict adherence and significant changes in eating habits, which can be challenging for individuals, particularly those already experiencing NDDs and other neurological disorders

If indeed OxD GSH was higher in rml1 than in the wild-type then the total glutathione level in the cytosol would have to be assumed to be slightly above 2% in order to reach an E GSH of 260 mV

Nature Reviews Genetics, 12 , 861874

"Vitamin D Deficiency among HIV Type 1-Infected Individuals in the Netherlands: Effects of Antiretroviral Therapy." AIDS Res Hum Retroviruses